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Buy Day today: Neutral (53) Mixed market breadth · no major macro event

Prime Medicine, Inc. Common Stock (PRME)

Healthcare Biotechnology
2.90 $
Closing price · As of: 31. Jul 2026
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Basics

Market Cap
0.5$B
Shares Outstanding
181Mio.
Float
63.7%
Beta
2.3

Performance

Perf. 1M
9.40%
Perf. 3M
10.10%
Perf. 6M
4.20%
YTD Performance (%)
-6.60%
52-Week-High Distance
-54.2%

Valuation

P/E
Forward P/E
0.0
PEG
P/B
7.4
P/S
136.5
EV/EBITDA
-3.1
Price/FCF

Profitability

Gross Margin
-3,722.0%
EBIT Margin
Net Margin
0.0%
Return on Equity
-216.1%
Return on Assets
-41.5%

Balance Sheet & Safety

Equity Ratio
Debt/Equity
1.5
warning zone
Altman Z″
-9.01
weak
Piotroski
1 out of 9

Growth

Sales Growth Last Quarter
-41.10%
EPS Growth Last Quarter
0.00%
Sales Growth (Year)
55.28%
Forward Sales Growth
109.15%
Forward EPS Growth
11.70%

Quality & Screener

Stage
4
RS Rating
32
EPS Rating
42
weak
Piotroski
1 out of 9
Fundamental Rating
D (34 out of 100)
warning zone
Altman Z″
-9.01

AI Rating

Not yet rated — we only show a category once an SEC-backed file with at least two cited passages is available. How the Rating Is Built

Highlighted are things our editorial team noticed: green = stands out as strong, red = deserves a closer look. No single metric is a verdict on its own — always read it in context.

Sales Per Quarter ($M)
2024: Q4 · 2.2 $M Q4 2025: Q1 · 1.5 $M Q1 2025: Q2 · 1.1 $M Q2 2025: Q3 · 1.2 $M Q3 2025: Q4 · 0.8 $M Q4 2026: Q1 · 0.9 $M Q1
Earnings Per Share Per Quarter ($)
2024: Q4 · -0.36 $ Q4 2025: Q1 · -0.40 $ Q1 2025: Q2 · -0.41 $ Q2 2025: Q3 · -0.32 $ Q3 2025: Q4 · -0.31 $ Q4 2026: Q1 · -0.28 $ Q1
Net Margin Per Quarter (%)
2024: Q4 · -1,936.6 % Q4 2025: Q1 · -3,568.8 % Q1 2025: Q2 · -4,716.7 % Q2 2025: Q3 · -4,129.1 % Q3 2025: Q4 · -5,498.7 % Q4 2026: Q1 · -5,738.6 % Q1
Operating Cash Flow Per Quarter ($M)
2024: Q4 · 16.2 $M Q4 2025: Q1 · -48.9 $M Q1 2025: Q2 · -41.4 $M Q2 2025: Q3 · -35.0 $M Q3 2025: Q4 · -37.3 $M Q4 2026: Q1 · -42.7 $M Q1
Free Cash Flow Per Quarter ($M)
2024: Q4 · 14.5 $M Q4 2025: Q1 · -51.3 $M Q1 2025: Q2 · -43.0 $M Q2 2025: Q3 · -35.3 $M Q3 2025: Q4 · -37.5 $M Q4 2026: Q1 · -42.9 $M Q1
Sales Growth vs. Year-Ago Quarter (%)
2024: Q4 · -91.5 % Q4 2025: Q1 · 146.0 % Q1 2025: Q2 · -97.0 % Q2 2025: Q3 · 486.1 % Q3 2025: Q4 · -61.6 % Q4 2026: Q1 · -41.1 % Q1
Price Change in Quarter (%)
2024: Q4 · -24.5 % Q4 2025: Q1 · -31.8 % Q1 2025: Q2 · 24.1 % Q2 2025: Q3 · 124.3 % Q3 2025: Q4 · -37.4 % Q4 2026: Q1 · 0.3 % Q1

Quarterly Figures

Quarterly Figures
Quarter EPS (Earnings Per Share) EPS YoY (%) Sales ($M) Sales YoY (%) Net Margin (%) OCF ($M) FCF ($M)
2024: Q4 -0.36 2 -91.50 -1,936.60 16 15
2025: Q1 -0.40 2 146.00 -3,568.80 -49 -51
2025: Q2 -0.41 1 -97.00 -4,716.70 -41 -43
2025: Q3 -0.32 1 486.10 -4,129.10 -35 -35
2025: Q4 -0.31 1 -61.60 -5,498.70 -37 -38
2026: Q1 -0.28 1 -41.10 -5,738.60 -43 -43
What Do These Terms Mean?
EPS (Earnings Per Share):
Quarterly profit divided by the total share count — how much of the profit works out to a single share.
YoY (Year over Year):
Change versus the same quarter a year ago — this is how you compare without seasonal distortion (e.g. the holiday shopping season).
Sales:
All revenue for the quarter, before any costs are deducted — the top line of the income statement.
Net Margin:
What percentage of sales is left over as profit in the end. Negative means the company is posting a loss.
OCF (Operating Cash Flow):
The cash that actually flows into the till from the core business during the quarter — harder to dress up than book profit.
FCF (Free Cash Flow):
Operating cash flow minus capital expenditures — the money that's genuinely free to use, say for paying down debt, buybacks, or dividends.

About the Company

Prime Medicine, Inc., ein Biotechnologieunternehmen, befasst sich mit der Bereitstellung genetischer Medizin zur Behandlung eines breiten Krankheitsspektrums durch den Einsatz von Gen-Editing-Technologie in den USA.

Employees146
HeadquartersCambridge, MA
Websiteprimemedicine.com
IPO Date20. Oct 2022
Next Earnings6. Aug 2026

Management

Management
Name Title Birth Year
Jeffrey D. Marrazzo M.B.A., M.P.A. Executive Chair 1979
Allan Reine M.D. CEO & Director 1975
Ann L. Lee Ph.D. Chief Technical Officer 1962
Andrew Anzalone M.D., Ph.D. Co-Founder 1987
David R. Liu Ph.D. Co-Founder & Member of Scientific Advisory Board
Svetlana Makhni Chief Financial Officer 1984
Ryan E. Brown J.D. Chief Legal Officer 1979
Niamh Alix Chief Human Resources Officer
Mohammed Asmal M.D., Ph.D. Chief Medical Officer
Matthew J. Hawryluk M.B.A., Ph.D. Chief Business Officer 1979

Executives per the latest required filings; titles kept in their original language. Source: fundamental data.

Chart

Interactive price chart (TradingView).

Data as of: July 31, 2026 · Source: fundamental data & SEC filings (annual and quarterly reports, 10-K/10-Q)

Note: pure fact-based analysis, not investment advice and not a solicitation to buy or sell. All figures without guarantee.

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