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Buy Day today: Neutral (53) Mixed market breadth · no major macro event

Protagonist Therapeutics Inc (PTGX)

Healthcare Biotechnology
136.60 $
Closing price · As of: 31. Jul 2026
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Basics

Market Cap
8.8$B
Shares Outstanding
64Mio.
Float
81.6%
Beta
1.8

Performance

Perf. 1M
21.10%
Perf. 3M
22.90%
Perf. 6M
36.90%
YTD Performance (%)
36.20%
52-Week-High Distance
-2.8%

Valuation

P/E
Forward P/E
27.9
PEG
P/B
13.4
P/S
118.4
EV/EBITDA
244.6
Price/FCF

Profitability

Gross Margin
100.0%
EBIT Margin
-6.5%
Net Margin
-154.9%
Return on Equity
-17.1%
Return on Assets
-12.4%

Balance Sheet & Safety

Equity Ratio
94.0%
Debt/Equity
0.02
fortress balance sheet
Altman Z″
21.79
Piotroski
6 out of 9

Growth

Sales Growth Last Quarter
99.00%
EPS Growth Last Quarter
351.30%
Sales Growth (Year)
-89.41%
Forward Sales Growth
-68.62%
Forward EPS Growth
-116.40%

Quality & Screener

Stage
2
RS Rating
87
Top 10%
EPS Rating
94
Piotroski
6 out of 9
Fundamental Rating
C (47 out of 100)
fortress balance sheet
Altman Z″
21.79

AI Rating

Not yet rated — we only show a category once an SEC-backed file with at least two cited passages is available. How the Rating Is Built

Highlighted are things our editorial team noticed: green = stands out as strong, red = deserves a closer look. No single metric is a verdict on its own — always read it in context.

Sales Per Quarter ($M)
2024: Q4 · 170.6 $M Q4 2025: Q1 · 28.3 $M Q1 2025: Q2 · 5.5 $M Q2 2025: Q3 · 4.7 $M Q3 2025: Q4 · 7.4 $M Q4 2026: Q1 · 56.4 $M Q1
Earnings Per Share Per Quarter ($)
2024: Q4 · 1.98 $ Q4 2025: Q1 · -0.19 $ Q1 2025: Q2 · -0.55 $ Q2 2025: Q3 · -0.62 $ Q3 2025: Q4 · -0.70 $ Q4 2026: Q1 · 0.05 $ Q1
Net Margin Per Quarter (%)
2024: Q4 · 77.2 % Q4 2025: Q1 · -41.2 % Q1 2025: Q2 · -627.0 % Q2 2025: Q3 · -834.9 % Q3 2025: Q4 · -596.8 % Q4 2026: Q1 · 6.7 % Q1
Operating Cash Flow Per Quarter ($M)
2024: Q4 · -29.2 $M Q4 2025: Q1 · 125.4 $M Q1 2025: Q2 · -28.8 $M Q2 2025: Q3 · -1.9 $M Q3 2025: Q4 · -37.0 $M Q4 2026: Q1 · -48.9 $M Q1
Free Cash Flow Per Quarter ($M)
2024: Q4 · -29.5 $M Q4 2025: Q1 · 124.8 $M Q1 2025: Q2 · -29.6 $M Q2 2025: Q3 · -2.0 $M Q3 2025: Q4 · -35.5 $M Q4 2026: Q1 · -49.2 $M Q1
Sales Growth vs. Year-Ago Quarter (%)
2024: Q4 · 184.4 % Q4 2025: Q1 · -88.9 % Q1 2025: Q2 · 33.1 % Q2 2025: Q3 · 0.8 % Q3 2025: Q4 · -95.6 % Q4 2026: Q1 · 99.0 % Q1
EPS Growth vs. Year-Ago Quarter (%)
2024: Q4 · 348.3 % Q4 2025: Q1 · -105.7 % Q1 2025: Q4 · -135.2 % Q4
Price Change in Quarter (%)
2024: Q4 · -14.2 % Q4 2025: Q1 · 25.3 % Q1 2025: Q2 · 14.3 % Q2 2025: Q3 · 20.2 % Q3 2025: Q4 · 31.5 % Q4 2026: Q1 · 20.7 % Q1

Quarterly Figures

Quarterly Figures
Quarter EPS (Earnings Per Share) EPS YoY (%) Sales ($M) Sales YoY (%) Net Margin (%) OCF ($M) FCF ($M)
2024: Q4 1.98 348.30 171 184.40 77.20 -29 -30
2025: Q1 -0.19 -105.70 28 -88.90 -41.20 125 125
2025: Q2 -0.55 6 33.10 -627.00 -29 -30
2025: Q3 -0.62 5 0.80 -834.90 -2 -2
2025: Q4 -0.70 -135.20 7 -95.60 -596.80 -37 -36
2026: Q1 0.05 56 99.00 6.70 -49 -49
What Do These Terms Mean?
EPS (Earnings Per Share):
Quarterly profit divided by the total share count — how much of the profit works out to a single share.
YoY (Year over Year):
Change versus the same quarter a year ago — this is how you compare without seasonal distortion (e.g. the holiday shopping season).
Sales:
All revenue for the quarter, before any costs are deducted — the top line of the income statement.
Net Margin:
What percentage of sales is left over as profit in the end. Negative means the company is posting a loss.
OCF (Operating Cash Flow):
The cash that actually flows into the till from the core business during the quarter — harder to dress up than book profit.
FCF (Free Cash Flow):
Operating cash flow minus capital expenditures — the money that's genuinely free to use, say for paying down debt, buybacks, or dividends.

About the Company

Protagonist Therapeutics, Inc. ist ein Forschungs- und Entwicklungsunternehmen in den USA.

CEO Insider Trades (12 Mo.)selling own stock
Employees131
HeadquartersNewark, CA
Websiteprotagonist-inc.com
IPO Date11. Aug 2016
Next Earnings5. Aug 2026

Management

Management
Name Title Birth Year
Dinesh V. Patel Ph.D. CEO, President, Secretary & Director 1957
Asif Ali Executive VP & CFO 1974
Arturo M. Molina FACP, M.D., M.S. Chief Medical Officer 1959
Venkat Thalladi Ph.D. EVP & Chief Technical Officer
Newman Yeilding M.D. Executive VP, Chief Scientific Officer
Matthew M. Gosling J.D. Executive VP and Chief Legal & Business Officer 1971
Carena Spivey Executive VP & Chief Human Resources Officer
Ashok Bhandari Ph.D. EVP & Chief Discovery Officer 1964
Carter J. King Executive Vice President of Business Development 1971
Abha Bommireddi Executive VP & Chief of Staff

Executives per the latest required filings; titles kept in their original language. Source: fundamental data.

Insider Transactions

Insider Transactions
Date Person Role Type Shares Price Value
20. Apr 2026 Asif Ali CFO Sell 1,750 105.47 184,573

Reportable transactions by officers and major shareholders from SEC Form 4 filings. "Other" includes things like stock grants and option exercises without a buy/sell character.

View all insider transactions →

Chart

Interactive price chart (TradingView).

Data as of: July 31, 2026 · Source: fundamental data & SEC filings (annual and quarterly reports, 10-K/10-Q)

Note: pure fact-based analysis, not investment advice and not a solicitation to buy or sell. All figures without guarantee.

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